Classification and application of metal-based nanoantioxidants in medicine and healthcare

• Nguyen Nhat Nam,
• Nguyen Khoi Song Tran,
• Tan Tai Nguyen,
• Nguyen Ngoc Trai,
• Nguyen Phuong Thuy,
• Hoang Dang Khoa Do,
• Nhu Hoa Thi Tran and
• Kieu The Loan Trinh

Beilstein J. Nanotechnol. 2024, 15, 396–415, doi:10.3762/bjnano.15.36

• nanotechnology, nanomaterials have emerged as a promising solution to improve the limitations of natural antioxidants because of their high stability, easy storage, time effectiveness, and low cost. Among various types of nanomaterials exhibiting antioxidant activity, metal-based nanoantioxidants show excellent

• biomedicine and nanotechnology for developing new types of antioxidants has witnessed a technological breakthrough that resulted in extraordinary progress in the pharmaceutical and biotechnology industries [7][8]. Moreover, many categories of nanomaterials have shown greater antioxidant activity and more

• action, and expand their applications, especially in medicine and healthcare. For example, the question of why nanoparticles with a majority of Ce3+ on the surface have stronger antioxidant activity than those with Ce4+ has recently been answered by Dutta and co-workers [11]. Ce3+ nanoparticles have a

Assessing phytotoxicity and tolerance levels of ZnO nanoparticles on Raphanus sativus: implications for widespread adoptions

• Pathirannahalage Sahan Samuditha,
• Nadeesh Madusanka Adassooriya and
• Nazeera Salim

Beilstein J. Nanotechnol. 2024, 15, 115–125, doi:10.3762/bjnano.15.11

• Tukey’s HSD test was employed to examine the statistical differences concerning soluble protein content, IAA, and Zn internalization. A two-sample t-test was employed to examine the statistical differences with respect to carbohydrates, plant pigments, and antioxidant activity. The results were expressed

Curcumin-loaded albumin submicron particles with potential as a cancer therapy: an in vitro study

• Nittiya Suwannasom,
• Netsai Sriaksorn,
• Chutamas Thepmalee,
• Krissana Khoothiam,
• Ausanai Prapan,
• Hans Bäumler and
• Chonthida Thephinlap

Beilstein J. Nanotechnol. 2023, 14, 1127–1140, doi:10.3762/bjnano.14.93

• promising biological properties, particularly antioxidant activity. However, its medical applications are limited due to its low water solubility, bioavailability, and pH-instability. CUR-loaded albumin microparticles (CUR-HSA-MPs) of submicron size in the range of 800 to 900 nm and a zeta potential of −15

Polymer nanoparticles from low-energy nanoemulsions for biomedical applications

• Santiago Grijalvo and
• Carlos Rodriguez-Abreu

Beilstein J. Nanotechnol. 2023, 14, 339–350, doi:10.3762/bjnano.14.29

• nanoparticles functionalized with the antibody 8D3. Afamin facilitates the transport of vitamin E to the central nervous system. When the nanoparticles were loaded with a drug, apolipoproteins involved in the transport through the BBB were also identified. Phytochemicals with antioxidant activity have been

• corona formation (upon incubation in FBS). The nanoparticles showed low cytotoxicity for SH-SY5Y cells (viabilities of ca. 100% for nanoparticle concentrations equal or lower than 0.23 mg/mL), high cellular uptake (in SH-SY5Y cells), and dose-dependent antioxidant activity. The properties of the PIC

Ethosomal (−)-epigallocatechin-3-gallate as a novel approach to enhance antioxidant, anti-collagenase and anti-elastase effects

• Çiğdem Yücel,
• Gökçe Şeker Karatoprak,
• Sena Yalçıntaş and
• Tuğba Eren Böncü

Beilstein J. Nanotechnol. 2022, 13, 491–502, doi:10.3762/bjnano.13.41

• collagenase and elastase enzymes were investigated compared to those of the solution form. Within the scope of antioxidant activity studies, 2,2-diphenyl-1-picrylhydrazyl (DPPH•) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS+•) radical scavenging and β-carotene/linoleic acid co-oxidation

• cytotoxicity test revealed that the formulations and the EGCG solution at different concentrations were nontoxic. In terms of cell permeability, enzyme inhibition, and antioxidant activity, the ethosomal formulations yielded better results compared to the EGCG solution. It was observed that the formulations

• products due to its safety and many benefits as a medicinal source. Epigallocatechin-3-gallate (EGCG), one of the major components of green tea, is a catechin-derived compound with a high antioxidant activity. It also has a protective effect against cardiovascular diseases, diabetes, cancer, and

Coordination-assembled myricetin nanoarchitectonics for sustainably scavenging free radicals

• Xiaoyan Ma,
• Haoning Gong,
• Kenji Ogino,
• Xuehai Yan and
• Ruirui Xing

Beilstein J. Nanotechnol. 2022, 13, 284–291, doi:10.3762/bjnano.13.23

• interaction (Myr/GSH = 1:2) [32][33][34]. The nanoparticles were formed by coordination self-assembly of Zn2+, Myr, and GSH (Figure 1a). They were expected to show good antioxidant activity to protect cells from the ROS-induced damage (Figure 1b). The transmission electron microscopy (TEM) image in Figure 2a

• strongest noncovalent interaction [4]. Hence, this interaction assured the stability of assembled nanoparticles in physiological conditions. Evaluation of ROS scavenging activity Myr possesses excellent antioxidant activity to scavenge ROS, which has impact on chelate metal ions such as Fe2+ and Cu2

• (equivalent concentration of Myr: 10, 20, 40, 80, and 100 µM) for 24 h. The lowest cell viability was approximately 80% at the highest tested concentration of MZG nanoparticles (Figure 4a). The result indicates that MZG nanoparticles did not affect the growth of 3T3 cells. The antioxidant activity of MZG

Comprehensive review on ultrasound-responsive theranostic nanomaterials: mechanisms, structures and medical applications

• Sepand Tehrani Fateh,
• Lida Moradi,
• Elmira Kohan,
• Michael R. Hamblin and
• Amin Shiralizadeh Dezfuli

Beilstein J. Nanotechnol. 2021, 12, 808–862, doi:10.3762/bjnano.12.64

A review on the biological effects of nanomaterials on silkworm (Bombyx mori)

• Sandra Senyo Fometu,
• Guohua Wu,
• Lin Ma and
• Joan Shine Davids

Beilstein J. Nanotechnol. 2021, 12, 190–202, doi:10.3762/bjnano.12.15

• remained active 12 h post-injection with a decline in antioxidant activity 36 h post injection. High concentrations of nanomaterials are detrimental to the organs and tissues of experimental animal models. For example, high concentrations of TiO2 NPs were reported to affect the reproduction of CD-1 mice

Scavenging of reactive oxygen species by phenolic compound-modified maghemite nanoparticles

• Małgorzata Świętek,
• Yi-Chin Lu,
• Rafał Konefał,
• Liliana P. Ferreira,
• M. Margarida Cruz,
• Yunn-Hwa Ma and
• Daniel Horák

Beilstein J. Nanotechnol. 2019, 10, 1073–1088, doi:10.3762/bjnano.10.108

• -diphenyl-1-picrylhydrazyl (DPPH) assay. Cellular uptake and intracellular antioxidant activity of the particles were evaluated by an iron assay and flow cytometry, respectively, using L-929 and LN-229 cells. Compared to the control, the phenolic modification significantly reduced intracellular reactive

• oxygen species (ROS) levels to 35–56%, which was associated with a 6–8-times higher cellular uptake in L-929 cells and a 21–31-times higher cellular uptake in LN-229 cells. In contrast, γ-Fe2O3@Hep particles induced a 3.8-times and 14.9-times higher cellular uptake without inducing antioxidant activity

• flavonoids and lignins have many functional groups attached to the multiple benzene rings within a single molecule. The simplest phenolic compounds consist of only one aromatic ring and a type, number, and arrangement of functional groups that strongly determine the antioxidant activity [5]. Generally

Fulleropeptide esters as potential self-assembled antioxidants

• Mira S. Bjelaković,
• Tatjana J. Kop,
• Jelena Đorđević and
• Dragana R. Milić

Beilstein J. Nanotechnol. 2015, 6, 1065–1071, doi:10.3762/bjnano.6.107

• precipitation and slow evaporation of the solvent, all compounds underwent spontaneous self-assembly giving ordered structures. The size and morphology of the resulting particles depend primarily on the sample concentration, and somewhat on the side chain structure. Keywords: antioxidant activity; cyclic

• , peptide, and steroid units [25], which possess in vitro antioxidant activity. Additionally, morphological characterization of self-organized structures of fullerene–steroid [26] and fullerene–peptide–steroid hybrids [25] in solution and in the solid state was studied by SEM. In our previous work [27], we

• antioxidant capacity. The antioxidant activity of 12 fullerene esters (as water soluble fullerosomes, obtained by liposome formation with soybean lecithin [31]) was determined by FOX antioxidant assay [32], using vitamin C and fullerene C60 as reference compounds. The FOX assay is based on the oxidation of

Nanobioarchitectures based on chlorophyll photopigment, artificial lipid bilayers and carbon nanotubes

• Marcela Elisabeta Barbinta-Patrascu,
• Stefan Marian Iordache,
• Ana Maria Iordache,
• Nicoleta Badea and
• Camelia Ungureanu

Beilstein J. Nanotechnol. 2014, 5, 2316–2325, doi:10.3762/bjnano.5.240

• radical scavenging ability (affording an antioxidant activity of 73.25%) and enhanced biocidal ability, offering inhibition zones of 12.4, 11.3 and 10.2 mm in diameter, against Escherichia coli, Staphylococcus aureus and Enterococcus faecalis, respectively. Keywords: antibacterial activity; antioxidant

• largely used as drug delivery vehicles, showing potential in targeting specific cancer cells [18] with a necessary dosage lower than conventional drugs, without harming healthy cells and significantly reduced side effects. Another interesting property of carbon nanotubes is their antioxidant activity

• Prima, NT-MDT, USA) in semi-contact mode (scanning area range 1.2 × 1.2 µm2) using an NSG01 cantilever with a typical radius of curvature of 10 nm. All AFM measurements were obtained on samples deposited on Si plate substrates. Chemiluminescence (CL) assay The in vitro antioxidant activity of the

Glassy carbon electrodes modified with multiwalled carbon nanotubes for the determination of ascorbic acid by square-wave voltammetry

• Sushil Kumar and
• Victoria Vicente-Beckett

Beilstein J. Nanotechnol. 2012, 3, 388–396, doi:10.3762/bjnano.3.45

• -wave voltammetry (SWV), have been employed as alternative tools for the evaluation of antioxidant activity [8]. These methods are attractive because of the speed of analysis, simplicity and low cost of the instrumental requirements. Ascorbic acid oxidation at a bare glassy carbon electrode (GCE